Relief shares are listed on the SIX Swiss Exchange under the valor symbol RLF and quoted on the U.S. OTCQB Venture Market under the symbol RLFTF
Share details (SIX)
International Reporting Standard
Nominal share value
Registered share capital (in shares)
Authorized capital band (in shares)
Conditional capital (in shares)
Global Emerging Markets (GEM)
Share details (U.S. OTCQB)
Share details (U.S. ADR OTCQB)
Shareholders who hold shares in a company incorporated in Switzerland whose equity securities are listed in Switzerland have the duty to disclose if they reach, exceed or fall below certain thresholds (3, 5, 10, 15, 20, 25, 33 1/3, 50, 66 2/3 % of voting rights).
The reporting form can be found at this link: www.ser-ag.com
We're refreshing our corporate presentation, coming soon!
|valuationLAB report, April 10, 2023
Relief shares are listed on the SIX Swiss Exchange and quoted on the U.S. OTCQB Venture
To view all documents filed with the SIX Swiss Exchange, please visit the “Notices Market Participants” section of ser-ag.com and select RELIEF THERAPEUTICS Holding AG in the Issuer filter.
We publish our half year and annual results in compliance with SIX requirements. Typically, this occurs in April and September of each fiscal year, respectively.
Our shares are listed on the SIX Swiss Exchange under the symbol RLF and are quoted in the U.S. on the OTCQB Market under the symbol RLFTF. Additionally, the Company has a level 1 U.S. ADR traded on the OTCQB under the symbol RLFTY.
Relief's stock is included, among others, in the Swiss Exchange Swiss Performance Index, the MSCI Global Small Cap Index, as well as the SXI Life Sciences and SXI Bio+Medtech indices.
As of June 30, 2023, there were 182'283 outstanding stock options under the Company's stock option plans and 1'800'000 outstanding warrants as issued in the June 2023 private placement. Each option and warrant allows its holder to acquire one share at a predetermined price.
Scientific publications on RLF-100™ can be view here: https://relieftherapeutics.com/pipeline..
We cannot speculate on the likelihood or timing of FDA approvals. In March 2021, Relief’s partner, NeuroRx, reported top-line 60-day results from the phase 2b/3 clinical trial in critical COVID-19 patients with respiratory failure. On the basis of these findings, in May 2021, NRx Pharmaceuticals, Inc. (NRx) (now the parent of NeuroRx) submitted an application to the FDA for Emergency Use Authorization (EUA), which was subsequently declined in November 2021. In January 2022, NRx announced that it had submitted an application to the FDA seeking EUA for the use of aviptadil to treat patients with critical COVID-19 who are at immediate risk of death from respiratory failure despite treatment with approved therapy including remdesivir and who are ineligible for enrollment into the ACTIV-3b NIH-sponsored trial, which was subsequently denied in July 2022.
The U.S. phase 2/3 study with the inhaled formulation of RLF-100® was initiated by NeuroRx, Inc. in February 2021. In March 2022, NRx announced the study was paused.
In September 2020, Relief entered into a binding collaboration agreement with NeuroRx (the “Collaboration Agreement”) which established the terms under which both parties would collaborate and assist each other to maximize the commercial value of each parties’ territories related to intravenous and inhaled aviptadil for the treatment of COVID-19 and other related pulmonary conditions. However, based on numerous breaches of the Collaboration Agreement by NeuroRx, in October 2021, Relief filed a lawsuit against NeuroRx and its then CEO, Dr. Jonathan Javitt, for multiple breaches of the Collaboration Agreement. The complaint, among other remedies, sought damages, an order compelling defendant to comply with multiple provisions of the Collaboration Agreement, and a declaration directing NeuroRx to deliver the entire data set from the Phase 2b/3 clinical trial of intravenously-administering aviptadil to Relief. On January 10, 2022, NeuroRx filed a complaint against Relief alleging that the Company is in breach of the Collaboration Agreement and has thus repudiated and cancelled the Collaboration Agreement. Additionally, NeuroRx’s claims include a count for defamation.
On November 14, 2022, Relief and NRx announced they had entered into a definitive settlement agreement to resolve all matters relating to the pending litigation. At the closing of this settlement, held on December 19, 2022, (i) NRx transferred to Relief all of the assets that it previously used in its aviptadil development program, including its regulatory filings, patent applications, clinical data, and the formulation of the aviptadil product it was previously developing, (ii) Relief has the exclusive right and control going forward to develop and commercialize an aviptadil product, (iii) Relief has agreed to use commercially reasonable efforts to continue the existing Right to Try Program for aviptadil in the United States for at least 2 years, (iv) Relief will pay NRx milestone payments if it can successfully obtain commercial approval of an aviptadil product (whether for COVID-19 or any other indication), (v) Relief will pay NRx royalties based on a percentage of future sales of an aviptadil product (whether for COVID-19 or any other indication), up to a maximum of $30 million in the aggregate, (vi) NRx Pharmaceuticals has agreed not to compete in the development of an aviptadil product in the future, and (vii) Relief and NRx Pharmaceuticals have dismissed their pending litigation.
Relief holds a patent covering potential formulations of RLF-100® in the United States valid until at least July 2029, with extension opportunities up to five years, as well as in the EU and Rest of World (Great Britain, Germany, Turkey, Spain, Switzerland, Netherlands, Denmark, Ireland, Austria, PRC and Mexico) valid until at least 2026, excluding extension opportunities comparable to the U.S. The acquisition of AdVita Lifescience GmbH in July 2021, enabled us to strengthen our intellectual property position with pending intellectual property rights that cover an improved formulation of the inhaled version of RLF-100® (aviptadil) and its potential application for the treatment of acute respiratory distress syndrome (“ARDS”) unrelated to COVID-19 infection, as well as in other pulmonary disorders, including sarcoidosis, berylliosis and checkpoint inhibitor-induced pneumonitis, for which AdVita has already filed pending patent claims.
OLPRUVA™ (sodium phenylbutyrate) (formerly know as ACER-001)
On August 14, 2023, Acer announced that OLPRUVA™ kits were commercially available in the U.S. in all dosage strengths. Acer also announced its intention to add commercial and medical affairs resources, and the introduction of its patient support service called OLPRUVA™ Navigator. Relief, in accordance with its exclusive license agreement with Acer, intends to submit a Marketing Authorization Application for approval of OLPRUVA for the treatment of UCDs in the U.K. and EU. There can be no assurance, however, that OLPRUVA will be approved for commercialization in the U.K. or the EU.
Scientific publications on OLPRUVA can be viewed here:
Our partnership terms and historic with Acer Therapeutics can be viewed here:
For investor inquiries contact:
Chief Financial Officer